Psychotropic medications (e.g. SSRIs, SNRIs, stimulants, etc.) do not create new serotonin, new dopamine, or new norepinephrine. Psychotropic medications redistribute what has already been made by the brain. To make those crucial neurotransmitters (that medications manipulate to treat symptoms), the brain needs: amino acid substrates (phenylalanine, tyrosine, tryptophan, methionine), the hydroxylase triad (BH4, iron [Fe], oxygen [O2]), PLP (vitamin B6) for decarboxylation, copper (Cu) and vitamin C (ascorbate) for dopamine β‑hydroxylase, and the full mitochondrial–methylation infrastructure (riboflavin [B2], niacin [B3], cobalamins [B12], folate [B9], magnesium [Mg], zinc [Zn], lipoate, CoA [B5], ATP, DHA [omega-3]).
Without adequate amounts of synthesized serotonin, dopamine, and norepinephrine in the brain, most psychotropic medications cannot meaningfully execute their mechanism(s) of action.
Monoamine-based treatments require monoamine-capable biology.
Restore psychiatry to medicine.